Fatigue is caused by multiple causes, the most important relate to the decrease in cortico-motor arousal and physiological changes in the muscle fibers of the heart and skeletal muscle. Psychological fatigue in many cases is due to chronic stress and in this case the levels of the hormone cortisol are increased.

Weekend athletes (sedentary during the week), sometimes abuse their cardiorespiratory capacity and have boosted immune system, so they are more susceptible to injury.

You need to be aware if the following symptoms of extreme fatigue or pain to appear:

- Pain in chest, arms (angina).

- Confusion, headache. Nausea and vomiting.

- Hyperthermia, 41,5º than rectal measurement and altered mental status.

- Muscle cramps and pains in legs.

- Hyponatremia with normal temperature.

- Pale by poor peripheral circulation.

- Difficulty breathing or running out of breath during exercise.

- Excessive palpitations, tachycardia (angina).

- Prolonged fatigue (lasting discomfort over 24 h).

- Insomnia (poor recovery of the heart).

- Fluid retention (weight gain due to poor recovery of the heart).

- If signs of dehydration are present with cardiovascular instability, such as sunken eyes or inability to spit.

The practice of strenuous exercise (more than 75% according to the person .; VO2max) long, causes acute but transient inflammation and oxidative stress may result if the free radicals that are produced are not neutralized by the antioxidant system. This transient inflammation (between 3-24 h.) After strenuous exercise causes a depression of the immune system that makes the athlete more vulnerable to respiratory and gastrointestinal infections during this time window occurs.

By contrast, the regular practice of moderate exercise (about 60 VO2max.); provides strengthening the immune system and antioxidant system due to over-compensation for the year. The also active on the expression of hundreds of genes intense exercise. These genes are involved in the production of pro / anti-inflammatory and stress proteins; and activation of growth factors and angiogenesis. The levels of cytokines activated time dependent: more pro-inflammatory during the year and more growth factors and anti-inflammatory after exercise and recovery phase.

Pro-inflammatory cytokines (IL-1, IL-6 and TNF-alpha in particular) and stress proteins are required for phase recovery and repair of damaged tissues by exercise; but if left unchecked inflammation continue to damage other healthy tissues of the athlete and are harmful to your health. The same applies in case of oxidative stress.

According to http://mirenadetox.com/mirena-side-effects/ Inflammation is a “double edged sword” as it eliminates pathogenic cells (bacteria, viruses, cancer cells), but if there is an exacerbation or inflammation continues over the account, removes and destroys its own tissues as well (such as gonads and thyroid).

Therefore if the recovery after exercise is correct, the anti-inflammatory IL-1ra citoqunas, IL10, tissue growth factors and other dampen inflammation; once they have been eliminated microdamage produced and replenished after damaged cells.

Interestingly, the involvement in the regulation of inflammation, which is performed by the hypothalamic-pituitary-adrenal cortex (HPA), where there are receptors for cytokines IL-1, IL-6, TNF-a released in inflammation that activate the HPA axis generating over hormone production (corticotropin releasing (CRH), which causes consequent lowering glucocorticoid production inflammation and suppress the immune system. One such glucocorticoid is cortisol hormone stress. When chronic stress is harmful. Is it harmful to add to the stress of work and real life of strenuous exercise.

Besides the strenuous exercise, some pathological situations (food allergies, obesity, eating disorders and gastrointestinal tract), cause changes in the immune system as a result of impaired nutritional status of the body, giving immunological abnormalities in different physiological and pathological conditions associated states of malnutrition.

The intense and prolonged exercise requires the consumption of large quantities of oxygen up to twenty times the general expenditure at rest and up to one hundred times the expenditure in muscle fibers used in addition due to breakage of the muscle fibers, heat stress and ischemia product of intense exercise, occurs in muscle tissue and a significant increase in neutrophils free radical. In the short term these free radicals (ROS) can not be neutralized by anti-oxidants generated by the body, so that the oxidative stress occurs. Oxidative stress that can damage DNA in leukocytes and can oxidize lipids, proteins or other molecules in the membranes; thereby causing cell damage.

Fortunately ROS act in turn triggering an intracellular signaling complex that triggers various cellular actions: increase of antioxidant enzymes that enhance the antioxidant system and restore redox homeostasis. All this depends on the cell type and the conditions under which oxidative stress occurs.

To keep the immune system (IS) and the antioxidant system in good condition, it is important to take a balanced diet with plenty of antioxidant vitamins (A, C, E), glutamine, minerals like zinc and selenium, probiotics and meet energy requirements. The effects of dietary antioxidants include decreased production of lactic acid in maximal exercise test, which means less suffering for the sportsman.

 

Physical and psychological recovery is therefore an essential part after prolonged exercise.

 

The psychological recovery is achieved with relaxation and rest.

 

Physical recovery improves with massage, stretching, good nutrition and hydration, to get faster:

 

Recovery of the damaged tissue injury and oxidative stress,

 

-Allow Cardiorespiratory and musculoskeletal development and increase the specific performance

 

-Training Adequate energy reserves (adenosine triphosphate, phosphocreatine, glycogen, lipids, proteins).

 

So for a healthy exercise program is essential to a good individualized training, good diet and emotional intelligence to manage stress.

For any doubt always consult your Doctor and Pharmacist

 

The UCI took the tip of a ball of doping in sport pedal lifetime sanctioned Lance Armstrong and withdrew won seven tour

Listen Willy, you’d better go on back roads, “was the first tip. The year was 1998 when the Festina team doctor made ​​the recommendation to the assistant Willy Voet. Why worry if Voet simply wearing material destined port of Calais at the start of the Tour de France, that started that year from Dublin? The car was a bomb. The traveling bag 400 doses of illegal products, especially EPO, the queen then, the magical potion undetectable. But Voet understood it was a formality. “What I was going to pass. We thought we were untouchable! It could go 200 kilometers on a highway and you salvabas giving him a jersey (shirt) the policeman on duty, “he said at the time the daily As. And made ​​the trip this July 8, the day before the Tour. In Neuville-en-Ferrain , a town on the French-Belgian border, was waiting crouched customs police. They went straight to the bag. They found the arsenal: EPO 200 ampoules, nearly 100 of growth hormone and testosterone dozen boxes. The equivalent strength and oxygen capsules. Voet was arrested. And hunting in what might be called the Die Potenzmittel kamagra, Sidalis, Hard on 120, Oral Jelly, super p force und Sidalis ohne Rezept bestellen began. Festina case that resulted in police lock-ups stuffed french open. As they marched cyclists, medical directors and Festina. Questioned.Treated as drug traffickers. Eco, Magic Potion How does EPO and why is not detected is the big question? Autotransfusion or EPO injections filled the bloodstream. Raise the hematocrit is the percentage of blood in the veins. Without exceeding the legal limit, 50%. But they have a side effect: the body reacts and stops producing these cells on their own. At that point stop doping controls. When they discover that an athlete tests stopped creating cells, light alarms. The detection method is Australian: measures the amount of reticulocytes, young red blood cells. If not, suspect. Of course, for every law there is a catch. The micro doses of EPO. The doctors believe that cheaters are undetectable.Its footprint disappears soon. So if 2000 units of EPO injected before, now reach 200. A drop in the blood stream. Although sufficient to arouse the production of red blood cells. And it confuses the controls. The fact is that the scandal that began in 1998 appears to have ended Monday with the lifetime ban the American cyclist Lance Armstrong, who gouged won all tours.Since then the bike was not the same. The shadow of doping always flew in all competitions. In 1999, several of the Mapei team cyclists were arrested; Vandenbroucke appeared implicated in a plot of doping and Pantani was expelled from Giro that was won by overcoming the rate of hematocrit. In 2001 the Giro became crazy records; Dario Frigo was expelled, and appeared a syringe with insulin in Pantani’s room. In 2002, Garzelli, leader of the Giro, tested positive. The Tour that year, Rumsas wife was arrested with a cargo of dopants. In the Vuelta 2004, Hamilton and Santiago Pérez fell through blood transfusion. A year later came the positive EPO Heras. In 2006 Operation Puerto doping found curled around Euphemianus doctor Fuentes. The client list: Ullrich, Basso, Sevilla, Mancebo, and teams Valencian Community and Liberty. The Tour Landis won that season. Three days later he jumped positive for testosterone. In 2007, Vinokourov tested positive for the Grande Boucle and Rasmussen, overall race leader, was set apart by having dodged two prior to the Tour doping controls your computer. And now a new pearl in the long necklace madness. King of the cycling world loses the crown. The world woke up shocked by the news that the International Cycling Union (UCI) decided to strip the American Lance Armstrong of his seven Tour titles in France and forbid compete for life. The council president, Pat McQuaid announced that the federation accepted the report of the United States Anti-Doping Agency on Armstrong. The decision allows organizers of the Tour officially remove the name of Armstrong’s book marks, canceling their consecutive wins from 1999 to 2005. Tour director Christian Prudhomme said failure to accept the ICU and in those years have not officially test winners. The decision is made ​​on Friday. Just in case: those who entered with a history behind Armstrong doping. McQuaid was very hard to convict around estaounidense rider “has no place in cycling, it is better to forget.” THE CRAZY RACE ARMSTRONG July 27 1999: Wins his first Tour de France. July 23, 2000: Wins his second Tour. In November, comes to light judicial investigation for doping during the Tour team. 2001: Conquer the Tour for the third year. He revealed that he had consulted the Italian doctor Michele Ferrari, implicated in the case by the use of EPO to beat the hour record.July 28, 2001: Win the Tour for the fourth time and is dismissed the case against him after undergoing urinalysis and blood in August. 2003: Wins Fifth Tour and divorces. 2004: Weeks before the start of the Tour, is accused of taking performance-enhancing drugs in the book by David Walsh and Pierre Ballester. 2004: Wins the sixth Tour France, becoming the winningest rider in the history of the gala event. 2004: His former assistant Mike Ardenson prohibited complaint found in his apartment and helped him escape Unannounced substances. April 18, 2005: Win seventh Tour and moves the world to retire. 2005: scandal a month of being away, L’Equipe reports that new positive tests for EPO in six of Armstrong’s urine samples allegedly taken during the 1999 Tour. 2006: In May is exonerated by the UCI doping allegations in 1999 because the controls were not developed under sound scientific standards. September 9, 2008: Announces his return to professional cycling. 2010: Landis admits he doped when he ran in the US Postal Service, and accuses several former teammates, including Armstrong. 2011: In January, a Sports Illustrated article quotes Stephen Swart, Armstrong mate in 1995, to claim that the seven-time Tour champion was the instigator for the team doparan with EPO. 2011: In February, announced his retirement from cycling high competition. 2011: In May another bomb: his former teammate Hamilton said he and Armstrong took EPO Tours in 1999, 2000 and 2001. June 13, 2012: USADA files formal charges against Armstrong for doping (blood transfusions, EPO, testosterone and corticosteroids) and is suspended. July 10, 2012: USADA sanctions lifetime three former employees of Armstrong’s US Postal participate in a systematic doping system. August 23, 2012: USADA anticipates that it will suspend for life and taken away all the titles won since 1998.August 24, 2012: USADA suspends and perpetual disqualification from all competitions in who participated. October 22, 2012: The UCI becomes effective lifetime ban and takes the prize won seven Tours.